PhD in Structural Biology

A 4-year PhD position in the research group of Dimphna Meijer, Department of Bionanoscience, Faculty of Applied Sciences, Delft University of Technology, Delft, Netherlands./nThe project focuses on cryo-EM and cryo-electron tomography (cryo-ET) imaging of reconstituted synapses to understand synapse assembly and disassembly at the molecular level, during health and disease. Methods include reconstituting minimal synaptic contacts and detailed structural characterization using cryo-ET and complementary light microscopy./nSpecific objectives include setting up a cryo-ET FIB SEM workflow for reconstituted synapses; visualizing nanoscale architecture of reconstituted synapses; high-resolution structure determination of synaptic cell adhesion molecule pairs; and confirmative structure-function studies in primary neurons.