PhD in Biophysics

The PhD student will develop and apply computational multiscale models to investigate brain energy metabolism and its relation to neurodegenerative diseases like Parkinson's disease and Alzheimer disease./nTo characterize the impact of mitochondrial morphology and regulation on the energetic state of brain cells, an agent-based physiological 3D model of mitochondria based on the seminal work of Prof. Skupin (https://www.nature.com/articles/s41598-019-54159-1) will be extended and embedded into a continuous description of single-cell models for neurons and glial cells (https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011464)./nThe goal of this hybrid continuum/agent-based model is to investigate through a quantitative mechanistic model how mitochondrial morphology affects energetic states and can integrate mechanistically experimental findings of neurodegenerative disease research./nLocation: Belval Campus.