PhD in Pharmacy

One PhD position in pharmacy is available in the group of Professor Carsten Uhd Nielsen at the Department of Physics, Chemistry and Pharmacy, University of Southern Denmark. Starting date of the position will be 1 April 2026 or as soon as possible thereafter./nProject background:/nAmino acid transporters have been implicated as possible drug targets in a number of diseases such as notably cancer. The project will investigate if allosteric inhibitors can be designed towards a number of transporters sharing the same protein structure folds (the LeuT-fold). The chosen transporters are LAT1, SNAT2 and PAT1. The project will do this via computational modeling and design using AlphaFold3.0 and available protein structures and ligand information, through make-on-demand compound libraries, and in vitro based cell systems. The aim is to find specific and selective inhibitors that will change how cancer cells grow and that can eventually be developed into a novel type of drugs./nResearch group:/nThe Drug Transporters in ADME group works with drug transporters from the SLC and ABC superfamilies mainly in cell cultures and preclinical animals to understand their role in drug targeting and in overall ADME. The group is international, cross-disciplinary and gender-balanced. The successful candidate will receive excellent training, mentoring and career development support./nLocation:/nDepartment of Physics, Chemistry and Pharmacy, SDU, Odense.