PhD in Bioinformatics And Computational Biology

Protein post-translational modifications (PTMs) are key regulatory mechanisms influencing protein stability, interactions, localisation, and signalling./nEmerging evidence shows that PTMs contribute significantly to complex disease biology, shaping metabolic, cognitive, and mental-health outcomes in the general population./nThe student will examine how predicted PTMs relate to continuous traits such as BMI, HbA1c, cognitive scores and mental-health outcomes (e.g., depression, anxiety), using statistical genetics, ML prediction models (elastic net, deep learning), and mediation frameworks to quantify indirect PTM-mediated effects./nThis multidisciplinary project integrates computational biology, structural modelling, population genomics, and AI and is based at the University of Surrey in Surrey, United Kingdom./nStart date: 1 October 2026.