PhD in Bioinformatics and Computational Biology

The Ziemert Lab at the University of Tübingen investigates the genomic diversity and evolution of natural product biosynthesis in bacteria and fungi./nThe group combines computational and experimental approaches to discover new antibiotics and other bioactive compounds, integrating comparative genomics, pangenomics, metagenomics, and genome mining with molecular biology and analytical chemistry to link biosynthetic gene clusters (BGCs) to their chemical products and biological functions./nThis PhD project aims to develop and modernize computational tools that enhance the discovery of novel bioactive compounds through genome mining. A central focus will be the further development of ARTS (Antibiotic Resistant Target Seeker), updating and expanding ARTS using modern computational methods including pangenome-based models, protein language models and structure-based comparisons, machine-learning approaches, and integration of metagenomic and fungal data.